We currently support a number of clinical research studies including:
ART-123: A multicentre double blind randomised phase III CTIMP (Clinical Trial of an Investigational Medical Product) for patients with severe sepsis and coagulopathy.
Biomarkers in Trauma: An observational study of major trauma patients testing sequential blood samples for specific immune biomarkers (T-Cells and Cytokines). The researchers want to develop a predictive model for organ dysfunction and mortality. This is in collaboration between Salford University and CMFT.
Catapult: A multi-centre double blind randomised phase II CTIMP of Stem Cell Therapy v Placebo in patients with ARDS (Acute Respiratory Distress Syndrome) a potentially life threatening condition.
IONA: Identification and characterisation of the clinical toxicology of Novel Psychoactive Substances (NPS) by laboratory analysis of biological samples from recreational drug users.
Bravo: A diagnostic study of patients with suspected VAP by the use of a Non-Invasive breath analysis device.to aid in antibiotic usage.
REST: A multi-centre randomised interventional study using the A-Lung extracorporeal CO2 removal system for patients with Acute Respiratory Failure/ ARDS. One of the aims is to reduce Tidal Volumes to 3-4 mls/kg
PRISM: Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial: A pragmatic randomised controlled trial of continuous positive airway pressure (CPAP) to prevent respiratory complications and improve survival following major abdominal surgery.
NO-Pac: Novel use of Tranexamic Acid to reduce the need for Nasal Packing in Epistaxis. Investigating a new treatment to help control nose bleeds.
Improving Tracheostomy Care:National Quality Improvement Programme. The Improving Tracheostomy Care (ITC) project aims to improve the care for tracheostomy patients everywhere through a large demonstration programme in geographically, demographically and politically diverse hospitals in the UK.
D-Dimer: Sample Collection in support of Clinical Performance Evaluation of the Roche Tina-quant® D-Dimer Gen. 2 assay for c4c family in the evaluation of patients with suspected Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE) with or without Deep Vein Thrombosis. To discover if a new blood test is as accurate as an existing one in diagnosing blood clots in the legs and lungs.
The 65 Trial: A multi-centre randomised study evaluating the clinical and cost-effectiveness of using a mean arterial pressure (MAP) target of 60 – 65 mmHg (permissive hypotension) in critically ill patients aged 65 years and over requiring vasopressor treatment.
Perspectives A mixed methods study using survey questionnaires and qualitative interviews to explore staff, patient and family member’s perspectives of research which is carried out within the Intensive Care Unit (ICU). The aim is to explore these perspectives to enable to enhance consent and recruitment within future research in intensive care units.
CADI study An observational study which investigates why patient’s admitted to the Intensive Care Unit (ICU) result in disruption to their natural body (circadian) rhythms. This is carried out by analysing additional blood samples to look at links between circadian rhythms and inflammation. Devices such as a small watch on your wrist can be used to monitor movement and a device can be placed near the bed to record light and noise intensity.
RESPECT A multi-centre mixed-methods evaluation of the use of the new national ReSEPCT (Recommended Summary Plan for Emergency Care and Treatment) process for adults being admitted to acute hospitals to determine how, when and why they are used and what effects they have on patient care.
For more information about these studies, please contact Senior Clinical Trials Co-ordinator for the EMERGING team, Katharine.Wylie@cmft.nhs.uk
