Clinical research studies

We currently support a number of clinical research studies, including:

  • ACTIVATION – Comparison of using ballooning and stenting for patients with severe narrowing of aortic valve requiring transcatheter aortic valve implantation (TAVI)
  • ARIADNE – Observational study to describe certain characteristics of Heart Failure patients for whom their doctor has prescribed medication
  • Cardio MEMS OUS – This Post Approval Study is evaluating the use of the CardioMEMS HF System in Heart Failure patients. It measures pulmonary artery pressure remotely from the patients home so medications can be adjusted accordingly.
  • COMMANDER HF – Study is to investigate if a drug, rivaroxaban, in combination with standard care medications can reduce the risk of a heart attack, stroke or death in patients with Heart Failure and Coronary Artery Disease
  • Deep Vein Thrombosis – Is Deep Vein Thrombosis an Under-recognised Complication of Electrophysiology Procedures? A Mechanistic Pilot Study Investigating Markers and Incidence of Thromboembolism
  • ERIC-PPCI – Comparison study to see if a simple technique of inflating and deflating a blood pressure cuff on the arm can help reduce the damage to the heart and improve recovery after a heart attack
  • EVOLVED – Early Valve Replacement guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis
  • HOMAGE – Investigating whether specialised blood tests can identify the risk of developing serious heart problems. Also to find out if a medicine called Spironolactone – a medication used for many years to treat high blood pressure – can also reduce that risk
  • IRONMAN – Comparing the effectiveness of intravenous iron treatment vs standard care in patients with heart failure and iron deficiency
  • ISCHEMIA – Comparing two standard treatments (PCI/CABG or OMT) for ischemia of the heart to determine which is more beneficial for patients
  • Medtronic Product Surveillance Registry: 1. Multi Point Pacing module and 2. Micra Acute Performance – Post-market product surveillance registry study to collect information about implanted leadless device and health
  • MERIT- Comparative study of using two different types of stents in patients with coronary artery disease
  • MILES – A patient registry monitoring the use of BioMime stent to treat narrowed arteries for future patients
  • MORE CRT MPP – Clinical investigation, evaluating the impact of a feature called Multi Point Pacing (MPP) in the treatment of patients that are not responding to standard Cardiac Resynchronisation Therapy (CRT)
  • PATTERN – A study of Physical Activity paTTerns and major health Events in older people with implantable cardiac devices
  • PIROUETTE – Study of the efficacy and safety of drug pirfenidone in patients with Heart failure
  • PRE18FFIR- Study to use heart scanning technique to look at high risk plaques in heart arteries
  • RAPID RHYTHM – A study to help measure how well a new piece of medical equipment works. The equipment is a new hand-held device capable of measuring heart rhythms (Electrocardiograph or ECG for short) more easily and quickly than the current method
  • REVIVED-BCIS2 – Comparing two options in treating heart failure patients
  • RIVER-UK – Learning more about the treatment and results in patients diagnosed with irregular heart beat in order to determine best practices in the future
  • Singulex Manchester Coronary Artery Disease Study (MFT Sponsored) – Highly Sensitive Troponin Assay to test troponin for patients attending Rapid Access Clinic to see if they are having a heart attack
  • SOLVE CRT – Cardiac Resynchrnoization Therapy (CRT) device using an ultrasound transmitter for non-responders and previously untreatable patients
  • SMART – registry – To learn in a general CRT-D population, which optimization techniques are used and how effective they are
  • SUPPORT HF – Investigating a home monitoring system to help patients with Heart Failure
  • SYNTAX II – Evaluating new method to assess the heart function in patients with triple disease who undergo percutaneous coronary intervention (PCI)
  • TAVI-QL – Exploring quality of life of patients undergoing heart valve replacement without surgery
  • TWILIGHT – Currently patients would remain on two medications for one year after PCI. This study aims to found out if both drugs are needed for this length of time or if one alone is as effective
  • UK TAVI – Comparison study looking at two ways of treating severe narrowing of aortic valve
  • WRAP-IT – Randomised study to see if antibiotic coated pouch can reduce infection of implanted cardiac device

For more information about these studies and other research at the Manchester Heart Centre please contact Senior Clinical Research Nurse Thabitha Charles on thabitha.charles@cmft.nhs.uk  or 0161 276 3336.