Clinical research studies

We currently support a number of clinical research studies, including:

  • BILAG – Biologics prospective cohort in systemic lupus erythematosus study
  • Ascore – Long-term experience with abatacept in routine clinical practice
  • TACERA – Towards a cure for early rheumatoid arthritis
  • APIPPRA – Looking into if giving treatment to at-risk patients before a diagnosis of rheumatoid arthritis can help prevent them going on to develop the disease
  • STRAP – This study will investigate whether different cell types in synovial tissue, which lines joints and becomes inflamed in people with rheumatoid arthritis, can help inform treatment decisions which will make biologic treatment success more likely first time
  • THERAPIST – investigating the potential factors causing some populations of rheumatoid arthritis patients to fail to have an adequate response to anti-TNFα therapies which are prescribed to patients who have failed to respond to disease-modifying anti-rheumatic drugs (DMARDS)
  • BRAGGSS – Aims to find out whether clinical, serological (Serum – is the fluid obtained when blood is separated into its solid and liquid components after it has been allowed to clot. It contains antibodies, which are made by the immune system to defend against infection), genetic and psychological factors influence rheumatoid arthritis or response to treatment
  • BSRBR RA national register – The register aims to find out if there are any long term side effects or health problems for rheumatoid arthritis patients on biologic therapies – find out more
  • RAMS – Rheumatoid arthritis methotrexate starters study. The study’s aim is to see whether researchers can predict which patients will do well and who will have to stop using common rheumatoid arthritis medication, methotrexate based on blood test results
  • Prevent RA – Pre-clinical evaluation of novel targets in rheumatoid arthritis, for relatives of patients with RA. The study will look at a number of factors for each person, including their genes, immune system and lifestyle environment to understand what makes people more likely or less likely to develop rheumatoid arthritis. Register for the study
  • AVERT 2 – The purpose of this study is to see if abatacept taken with methotrexate is better than methotrexate alone in providing a significant improvement in rheumatoid arthritis (RA) for patients who have been recently diagnosed with RA and haven’t started any other treatment
  • LEAP – A study for patients with lupus and other connective tissue disease
  • TULIP – Study for patients with lupus as there are few treatment options for patients with active lupus. It is trialling a new drug called Anifrolumab
  • EMBRACE – Looking to find out if a drug called Belimumab is effective and safe in treating patients of black ethnic minority who have lupus.
  • Future 5 – Trialling a new drug for patients with active psoriatic arthristis called secukinumab. Patients will be followed up for 2 years.
  • OUTPASS – Study led by The University of Manchester. The study aims to find out whether clinical, serological (Serum is the fluid obtained when blood is separated into its solid and liquid components after it has been allowed to clot. It contains antibodies, which are made by the immune system to defend against infection), genetic and psychological factors influence Psoriatic Arthritis or response to treatment.
  • DC VAS study – The term vasculitis refers to a group of diseases where inflammation of blood vessels is the common feature. This study will allow us to improve our ability to distinguish patients with vasculitis from those who do not have it (diagnostic criteria), and also to distinguish between different forms of vasculitis (classification criteria).
  • We are currently running a study looking at memory, concentration and attention in patients with lupus and fibromyalgia. At the moment we are specifically looking for patients with fibromyalgia. Find out more by emailing michelle.barraclough@manchester.ac.uk.

For more information about these studies and other research at The Kellgren Centre for Rheumatology please contact Senior Research Nurse rheumatology.research@cmft.nhs.uk or 0161 276 4358.